Biomechanical, ultrastructural, and electrophysiological characterization of the non-human primate experimental glaucoma model.

ABSTRACT: Laser-induced experimental glaucoma (ExGl) in non-human primates (NHPs) is a common animal model for ocular drug development. While many features of human hypertensive glaucoma are replicated in this model, structural and functional changes in the unlasered portions of trabecular meshwork (TM) of laser-treated primate eyes are understudied. We studied NHPs with ExGl of several years duration. As expected, ExGl eyes exhibited selective reductions of the retinal nerve fiber layer that correlate with electrophysiologic measures documenting a link between morphologic and elctrophysiologic endpoints. Softening of unlasered TM in ExGl eyes compared to untreated controls was observed. The degree of TM softening was consistent, regardless of pre-mortem clinical findings including severity of IOP e

SUBMITTER: Raghunathan V 

PROVIDER: S-EPMC5662689 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature