Highly Sensitive Plasmonic Detection of the Pancreatic Cancer Biomarker CA 19-9.

ABSTRACT: Plasmonic gold (Au) nanotriangular arrays, functionalized with a near infrared (NIR) fluorophore-conjugated immunoassay to Carbohydrate Antigen 19-9 (CA 19-9), a pancreatic cancer biomarker, produce optically tunable substrates with two orders of magnitude fluorescence enhancement. Through nanoscale morphological control, the sensitivities of the plasmonic nanotriangular arrays are controllable, paving the way of such optical platforms for multiplexing. Here, we report a limit of detection (LOD) of 7.7 × 10^-7 U.mL^-1 for CA 19-9 by using such tunable Au nanotriangular arrays, a great improvement compared to commercially available CA 19-9 immunoassays. The linear dynamic range was from 1 × 10^-6 U.mL^-1 to 1 U.mL^-1, i.e. up to six orders o

SUBMITTER: Jawad ZAR 

PROVIDER: S-EPMC5662715 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature