Identification of New Features from Known Bacterial Protective Vaccine Antigens Enhances Rational Vaccine Design.

ABSTRACT: With many protective vaccine antigens reported in the literature and verified experimentally, how to use the knowledge mined from these antigens to support rational vaccine design and study underlying design mechanism remains unclear. In order to address the problem, a systematic bioinformatics analysis was performed on 291 Gram-positive and Gram-negative bacterial protective antigens with experimental evidence manually curated in the Protegen database. The bioinformatics analyses evaluated included subcellular localization, adhesin probability, peptide signaling, transmembrane α-helix and β-barrel, conserved domain, Clusters of Orthologous Groups, and Gene Ontology functional annotations. Here we showed the critical role of adhesins, along with subcellular localization, peptide signaling,

SUBMITTER: Ong E 

PROVIDER: S-EPMC5662880 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature