Widespread activation of antisense transcription of the host genome during herpes simplex virus 1 infection.

ABSTRACT:

Background

Herpesviruses can infect a wide range of animal species. Herpes simplex virus 1 (HSV-1) is one of the eight herpesviruses that can infect humans and is prevalent worldwide. Herpesviruses have evolved multiple ways to adapt the infected cells to their needs, but knowledge about these transcriptional and post-transcriptional modifications is sparse.

Results

Here, we show that HSV-1 induces the expression of about 1000 antisense transcripts from the human host cell genome. A subset of these is also activated by the closely related varicella zoster virus. Antisense transcripts originate either at gene promoters or within the gene body, and they show different susceptibility to the inhibition of early and immediate early viral gene expression. Overexpression of the maj

SUBMITTER: Wyler E 

PROVIDER: S-EPMC5663069 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature