Identifying factors associated with the direction and significance of microRNA tumor-normal expression differences in colorectal cancer.

ABSTRACT:

Background

microRNAs are small non-protein-coding RNA molecules that regulate gene expression, and have a potential epigenetic role in disease progression and survival of colorectal cancer. In terms of tumor-normal expression differences, many microRNAs exhibit evidence of being up-regulated in some subjects but down-regulated in others, or are dysregulated only for a subset of the population. We present and implement an approach to identify factors (lifestyle, tumor molecular phenotype, and survival-related) that are associated with the direction and/or significance of these microRNAs' tumor-normal expression differences in colorectal cancer.

Methods

Using expression data for 1394 microRNAs and 1836 colorectal cancer subjects (each with both tumor and normal samples), we pe

SUBMITTER: Stevens JR 

PROVIDER: S-EPMC5663119 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature