Subfunctionalization influences the expansion of bacterial multidrug antibiotic resistance.

ABSTRACT:

Background

Antibiotic resistance is a major problem for human health. Multidrug resistance efflux pumps, especially those of the Resistance-Nodulation-Cell Division (RND) family, are major contributors to high-level antibiotic resistance in Gram-negative bacteria. Most bacterial genomes contain several copies of the different classes of multidrug resistance efflux pumps. Gene duplication and gain of function by the duplicate copies of multidrug resistance efflux pump genes plays a key role in the expansion and diversification of drug-resistance mechanisms.

Results

We used two members of the Burkholderia RND superfamily as models to understand how duplication events affect the antibiotic resistance of these strains. First, we analyzed the conservation and distribution of thes

SUBMITTER: Perrin E 

PROVIDER: S-EPMC5663151 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature