Long-term Pulmonary Outcomes in Pediatric Survivors of High-risk Neuroblastoma.

ABSTRACT:

Background

Children with high-risk neuroblastoma are exposed to multimodality therapies early in life and survivors confront late therapy-related toxicities. This study assessed respiratory symptoms, pulmonary function tests (PFTs), and risk factors for abnormalities among survivors.

Materials and methods

High-risk neuroblastoma survivors followed in the long-term follow-up clinic at Memorial Sloan Kettering Cancer Center were enrolled. Self-administered symptom questionnaires were completed. Medical records were reviewed for treatment information and comorbidities. PFTs included spirometry, plethysmography, and diffusion capacity of the lung for carbon monoxide (DLCO).

Results

Thirty-nine survivors participated (median age at study: 11.4 y; median age at diagnosis: 2

SUBMITTER: Stone A 

PROVIDER: S-EPMC5663196 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature