Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning.

ABSTRACT: Changes in cortical and striatal function underlie the transition from novel actions to refined motor skills. How discrete, anatomically defined corticostriatal projections function in vivo to encode skill learning remains unclear. Using novel fiber photometry approaches to assess real-time activity of associative inputs from medial prefrontal cortex to dorsomedial striatum and sensorimotor inputs from motor cortex to dorsolateral striatum, we show that associative and sensorimotor inputs co-engage early in action learning and disengage in a dissociable manner as actions are refined. Disengagement of associative, but not sensorimotor, inputs predicts individual differences in subsequent skill learning. Divergent somatic and presynaptic engagement in both projections during early action lea

SUBMITTER: Kupferschmidt DA 

PROVIDER: S-EPMC5663197 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature