Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes.

ABSTRACT: Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional mitochondria from cells is of great importance toward understanding the molecular events involved in the genesis of cardiomyopathy. Earlier studies have ascribed a role for BAG3 in the development of cardiomyopathy in experimental animals leading to the identification of BAG3 mutations in patients with heart failure which may play a part in the onset of disease development and progression. BAG3 is co-chaperone of heat shock protein 70 (HSP70), which has been shown to modulate apoptosis and autophagy, in several cell models. In this study, we explore the potential role of BAG3 in mitochondrial quality control. We demonstrate that siRN

SUBMITTER: Tahrir FG 

PROVIDER: S-EPMC5663276 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature