A Biocatalytic Route to Highly Enantioenriched β-Hydroxydioxinones.

ABSTRACT: A novel biocatalytic system to access a wide variety of β-hydroxydioxinones from β-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in β-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability.

SUBMITTER: Betori RC 

PROVIDER: S-EPMC5663308 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature