Development of an interstitial cystitis risk score for bladder permeability.

ABSTRACT:

Background

Interstitial cystitis/bladder pain syndrome (IC) is a multifactorial syndrome of severe pelvic and genitalia pain and compromised urinary function; a subset of IC patients present with Hunner's lesions or ulcers on their bladder walls (UIC). UIC is diagnosed by cystoscopy, which may be quite painful. The objective of this study was to determine if a calculated Bladder Permeability Defect Risk Score (BP-RS) based on non-invasive urinary cytokines could discriminate UIC patients from controls and IC patients without Hunner's ulcers.

Methods

A national crowdsourcing effort targeted IC patients and age-matched controls to provide urine samples. Urinary cytokine levels for GRO, IL-6, and IL-8 were determined using a Luminex assay.

Results

We collected 448 urine

SUBMITTER: Lamb LE 

PROVIDER: S-EPMC5663335 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature