Development of a multiplex serological assay reveals a worldwide distribution of murine astrovirus infections in laboratory mice.

ABSTRACT: Laboratory mice play a tremendous role in biomedical research in studies on immunology, infection, cancer and therapy. In the course of standardization of mice used in animal experiments, health monitoring constitutes an important instrument towards microbiological standardization. Infections with murine astroviruses (MuAstV) were only recently discovered and are, therefore, still relatively unknown in laboratory animal science. In rodent health monitoring viral infections within a population are commonly assessed in terms of specific antibodies by serological testing, as active infection and excretion of virus is often temporary and can easily be missed. So far only ongoing infections with astroviruses can be detected by PCR. The objective of this work was the development of a sensitive a

SUBMITTER: Schmidt K 

PROVIDER: S-EPMC5663422 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature