Deconvolving sequence features that discriminate between overlapping regulatory annotations.

ABSTRACT: Genomic loci with regulatory potential can be annotated with various properties. For example, genomic sites bound by a given transcription factor (TF) can be divided according to whether they are proximal or distal to known promoters. Sites can be further labeled according to the cell types and conditions in which they are active. Given such a collection of labeled sites, it is natural to ask what sequence features are associated with each annotation label. However, discovering such label-specific sequence features is often confounded by overlaps between the labels; e.g. if regulatory sites specific to a given cell type are also more likely to be promoter-proximal, it is difficult to assess whether motifs identified in that set of sites are associated with the cell type or associated with

SUBMITTER: Kakumanu A 

PROVIDER: S-EPMC5663517 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature