Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.

ABSTRACT: The potentiation of the naturally limited regenerative capacity of the heart is dependent on an understanding of the mechanisms that are activated in response to pathological conditions such as hypoxia. Under these conditions, the expression of genes suggested to support cardiomyocyte survival and heart adaptation is triggered. Particularly important are changes in the expression of myosin heavy chain (MHC) isoforms. We propose here that alterations in the expression profiles of MHC genes are induced in response to hypoxia and are primarily mediated by hypoxia inducible factor (HIF). In in vitro models of mouse embryonic stem cell-derived cardiomyocytes, we showed that hypoxia (1% O₂) or the pharmacological stabilization of HIFs significantly increased MHCbeta (Myh7

SUBMITTER: Bino L 

PROVIDER: S-EPMC5663546 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature