T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation.

ABSTRACT:

Background

The T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of the alloreactive T-cell response within secondary lymphoid organs is important after organ transplantation. However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation.

Methods

T cells from LNs of ESRD patients were analyzed for frequency of recent thymic emigrants, relative telomere length, expression of differentiation markers, and were related to the development of early acute rejection (EAR), occurring within 3 months after renal transplantation (RT). Furthermore, the alloreactive potential of mononuclear cells isolated from the LN and peripher

SUBMITTER: Dedeoglu B 

PROVIDER: S-EPMC5663687 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature