An individualized gene expression signature for prediction of lung adenocarcinoma metastases.

ABSTRACT: Our laboratory previously reported an individual-level signature consisting of nine gene pairs, named 9-GPS. This signature was developed by training on microarray expression data and validated using three independent integrated microarray data sets, with samples of stage I non-small-cell lung cancer after complete surgical resection. In this study, we first validated the cross-platform robustness of 9-GPS by demonstrating that 9-GPS could significantly stratify the overall survival of 213 stage I lung adenocarcinoma (LUAD) patients detected with RNA-sequencing platform in The Cancer Genome Atlas (TCGA; log-rank P = 0.0318, C-index = 0.55). Applying 9-GPS to all the 423 stage I-IV LUAD samples in TCGA, the predicted high-risk samples were significantly enriched with clinically diagnosed me

SUBMITTER: Qi L 

PROVIDER: S-EPMC5663997 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature