Novel landscape of HLA-G isoforms expressed in clear cell renal cell carcinoma patients.

ABSTRACT: Immune checkpoints are powerful inhibitory molecules that promote tumor survival. Their blockade is now recognized as providing effective therapeutic benefit against cancer. Human leukocyte antigen G (HLA-G), a recently identified immune checkpoint, has been detected in many types of primary tumors and metastases, in malignant effusions as well as on tumor-infiltrating cells, particularly in patients with clear cell renal cell carcinoma (ccRCC). Here, in order to define a possible anticancer therapy, we used a molecular approach based on an unbiased strategy that combines transcriptome determination and immunohistochemical labeling, to analyze in-depth the HLA-G isoforms expressed in these tumors. We found that the expression of HLA-G is highly variable among tumors and distinct areas of t

SUBMITTER: Tronik-Le Roux D 

PROVIDER: S-EPMC5664004 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature