Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease.

ABSTRACT:

Importance

The activity of lipoprotein lipase (LPL) is the rate-determining step in clearing triglyceride-rich lipoproteins from the circulation. Mutations that damage the LPL gene (LPL) lead to lifelong deficiency in enzymatic activity and can provide insight into the relationship of LPL to human disease.

Objective

To determine whether rare and/or common variants in LPL are associated with early-onset coronary artery disease (CAD).

Design, setting, and participants

In a cross-sectional study, LPL was sequenced in 10 CAD case-control cohorts of the multinational Myocardial Infarction Genetics Consortium and a nested CAD case-control cohort of the Geisinger Health System DiscovEHR cohort between 2010 and 2015. Common variants were genotyped in up to 305 699 individuals

SUBMITTER: Khera AV 

PROVIDER: S-EPMC5664181 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature