Strategies to alter the natural history of childhood asthma.

ABSTRACT:

Purpose of review

Asthma exhibits significant heterogeneity in occurrence and severity over the lifespan. Our goal is to discuss recent evidence regarding determinants of the natural history of asthma during childhood, and review the rationale behind and status of major efforts to alter its course.

Recent findings

Variations in microbial exposures are associated with risk of allergic disease, and the use of bacterial lysates may be a promising preventive strategy. Exposure to air pollution appears to be particularly damaging in prenatal and early life, and interventions to reduce pollution are feasible and result in clinical benefit. E-cigarette use may have a role in harm reduction for conventional cigarette smokers with asthma, but has undefined short-term and long-term ef

SUBMITTER: Lee-Sarwar KA 

PROVIDER: S-EPMC5664210 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature