Female sex, early-onset hypertension, and risk of dementia.

ABSTRACT:

Objective

To evaluate the association of early-adulthood and mid-adulthood hypertension with dementia in men and women.

Methods

We evaluated 5,646 members of a diverse integrated health care delivery system who had clinical examinations and health survey data from 1964 to 1973 (mean age 32.7 years; early adulthood) and 1978-1985 (mean age 44.3 years; mid-adulthood) and were members as of January 1, 1996 (mean age 59.8 years). Hypertension categories based on measurements of blood pressure (BP) and change in hypertension categories between the 2 examinations (e.g., onset hypertension) were used to predict dementia incidence from January 1, 1996, to September 30, 2015. Cox proportional hazard models were adjusted for demographics, vascular comorbidities, and hypertension treat

SUBMITTER: Gilsanz P 

PROVIDER: S-EPMC5664296 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature