Metformin vs sulfonylurea use and risk of dementia in US veterans aged ≥65 years with diabetes.

ABSTRACT:

Objective

To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas.

Methods

This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therapy. To account for confounding by indication, we developed a propensity score (PS) and used inverse probability of treatment weighting (IPTW) methods. Cox proportional hazards models estimated the hazard ratio (HR) of incident dementia.

Results

We identified 17,200 new users of metformin and 11,440 new users of sulfonylureas. Mean age was 73.5 years and mean HbA1c was 6.8%. Over an average follow-up of 5 years, 4,906 cases of dementia were diagnosed. Due t

SUBMITTER: Orkaby AR 

PROVIDER: S-EPMC5664297 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature