Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease.

ABSTRACT:

Objective

To determine whether MRI markers, including diffusion tensor imaging (DTI), can predict cognitive decline and dementia in patients with cerebral small vessel disease (SVD).

Methods

In the prospective St George's Cognition and Neuroimaging in Stroke study, multimodal MRI was performed annually for 3 years and cognitive assessments annually for 5 years in a cohort of 99 patients with SVD, defined as symptomatic lacunar stroke and confluent white matter hyperintensities (WMH). Progression to dementia was determined in all patients. Progression of WMH, brain volume, lacunes, cerebral microbleeds, and a DTI measure (the normalized peak height of the mean diffusivity histogram distribution) as a marker of white matter microstructural damage were determined.

Results

SUBMITTER: Zeestraten EA 

PROVIDER: S-EPMC5664300 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature