Brain network connectivity differs in early-onset neurodegenerative dementia.

ABSTRACT:

Objective

To investigate functional brain network architecture in early-onset Alzheimer disease (EOAD) and behavioral variant frontotemporal dementia (bvFTD).

Methods

Thirty-eight patients with bvFTD, 37 patients with EOAD, and 32 age-matched healthy controls underwent 3D T1-weighted and resting-state fMRI. Graph analysis and connectomics assessed global and local functional topologic network properties, regional functional connectivity, and intrahemispheric and interhemispheric between-lobe connectivity.

Results

Despite similarly extensive cognitive impairment relative to controls, patients with EOAD showed severe global functional network alterations (lower mean nodal strength, local efficiency, clustering coefficient, and longer path length), while patients with bv

SUBMITTER: Filippi M 

PROVIDER: S-EPMC5664301 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature