Mixed neuropathologies and associations with domain-specific cognitive decline.

ABSTRACT:

Objective

To test whether decline in specific cognitive domains associated with Alzheimer disease neuropathologic change (ADNC) is modified by co-occurrence of other neuropathologies such as Lewy body disease (LBD) or vascular brain injury (VBI).

Methods

Data came from 1,603 autopsied participants evaluated at US Alzheimer's Disease Centers. Standardized z scores in memory, attention, language, and executive function were derived from neuropsychological test scores assessed at each annual visit. Multivariable linear mixed-effects models assessed associations between neuropathologies and longitudinal trajectories of domain scores.

Results

Compared to other participants, those with ADNC + LBD generally had worse cognitive trajectories, particularly lower initial

SUBMITTER: Brenowitz WD 

PROVIDER: S-EPMC5664309 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature