Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites.

ABSTRACT: A basic scheme of neuronal organization in the mammalian retina is the segregation of ON and OFF pathways in the inner plexiform layer (IPL), where glutamate is released from ON and OFF bipolar cell terminals in separate inner (ON) and outer (OFF) sublayers in response to light intensity increments and decrements, respectively. However, recent studies have found that vGluT3-expressing glutamatergic amacrine cells (GACs) generate ON-OFF somatic responses and release glutamate onto both ON and OFF ganglion cell types, raising the possibility of crossover excitation in violation of the canonical ON-OFF segregation scheme. To test this possibility, we recorded light-evoked Ca²⁺ responses from dendrites of individual GACs infected with GCaMP6s in mouse. Under two-photon imaging, a si

SUBMITTER: Chen M 

PROVIDER: S-EPMC5664540 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature