Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.

ABSTRACT: High-risk human papillomaviruses (HPVs) infect epithelial cells and are causally associated with cervical cancer, but HPV infection is not sufficient for carcinogenesis. Previously, we reported that estrogen signaling in the stromal tumor microenvironment is associated with cervical cancer maintenance and progression. We have now determined how HPV oncogenes and estrogen treatment affect genome-wide host gene expression in laser-captured regions of the cervical epithelium and stroma of untreated or estrogen-treated nontransgenic and HPV-transgenic mice. HPV oncogene expression in the cervical epithelium elicited significant gene-expression changes in the proximal stromal compartment, and estrogen treatment uniquely affected gene expression in the cervical microenvironment of HPV-transgenic

SUBMITTER: Spurgeon ME 

PROVIDER: S-EPMC5664542 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature