Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation.

ABSTRACT: It has been shown that γδ T cells protect against the formation of squamous cell carcinoma (SCC) in several models. However, the role of γδ T cells in human papillomavirus (HPV)-associated uterine cervical SCC, the third-leading cause of death by cancer in women, is unknown. Here, we investigated the impact of γδ T cells in a transgenic mouse model of carcinogenesis induced by HPV16 oncoproteins. Surprisingly, γδ T cells promoted the development of HPV16 oncoprotein-induced lesions. HPV16 oncoproteins induced a decrease in epidermal Skint1 expression and the associated antitumor Vγ5⁺ γδ T cells, which were replaced by γδ T-cell subsets (mainly Vγ6⁺ γδ^lowCCR2⁺CCR6^-) actively producing IL-17A. Consistent with a proangiogenic role, γδ T c

SUBMITTER: Van Hede D 

PROVIDER: S-EPMC5664550 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature