Circular RNA profiles in mouse lung tissue induced by radon.

ABSTRACT:

Background

Radon is a known human lung carcinogen, whose underlying carcinogenic mechanism remains unclear. Recently, circular RNA (circRNA), a class of endogenous non-protein coding RNAs that contain a circular loop, was found to exhibit multiple biological effects. In this study, circRNA profiles in mouse lung tissues between control and radon exposure were analyzed.

Methods

Six mice were exposed to radon at concentration of 100,000 Bq/m³, 12 h/d, for up to cumulative doses of 60 working level months (WLM). H&E staining and immunohistochemistry of caspase-3 were used to detect the damages in lung tissue. The lung tissue of control and exposed group were selected for circRNA microarray study. The circRNA/microRNA interaction was analyzed by starBase prediction so

SUBMITTER: Pei W 

PROVIDER: S-EPMC5664590 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature