Tigecycline Resistant Klebsiella pneumoniae Isolated from Austrian River Water.

ABSTRACT: Abstract: Antibiotic-resistant bacteria are spreading worldwide in medical settings but also in the environment. These resistant bacteria illustrate a major health problem in our times, and last-line antibiotics such as tigecycline represent an ultimate therapy option. Reports on tigecycline non-susceptible Enterobacteriaceae are presented with regard to medical settings but are rare with that for the environment. The aim of this study was to characterize two tigecycline non-susceptible Klebsiella pneumoniae isolates from the river Mur, and to question the resistance mechanism. The screening for chromosomal mutations revealed a deletion and a silent point mutation in one isolate and a point mutation in the other isolate all within the ramR allele. RamR acts as repressor and prevents overex

SUBMITTER: Hladicz A 

PROVIDER: S-EPMC5664670 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature