Actionable gene-based classification toward precision medicine in gastric cancer.

ABSTRACT:

Background

Intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC patients, an actionable gene alteration-based molecular classification that directly associates GCs with targeted therapies is needed.

Methods

A total of 207 Japanese patients with GC were included in this study. Formalin-fixed, paraffin-embedded (FFPE) tumor tissues were obtained from surgical or biopsy specimens and were subjected to DNA extraction. We generated comprehensive genomic profiling data using a 435-gene panel including 69 actionable genes paired with US Food and Drug Administration-approved targeted therapies, and the evaluation of Epstein-Barr virus (EBV) infection and microsatellite inst

SUBMITTER: Ichikawa H 

PROVIDER: S-EPMC5664811 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature