Transcriptomic study of Salmonella enterica subspecies enterica serovar Typhi biofilm.

ABSTRACT:

Background

Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). In chronic carriers, the bacteria survive the harsh environment of the gallbladder by producing biofilm. The phenotype of S. Typhi biofilm cells is significantly different from the free-swimming planktonic cells, and studies have shown that they are associated with antibiotic resistance, immune system evasion, and bacterial persistence. However, the mechanism of this transition and the events leading to biofilm formation are unknown. High throughput sequencing was performed to identify the genes involved in biofilm formation and to postulate the mechanism of action.

Results

Planktonic S. Typhi cells were cultured using standard nutrien

SUBMITTER: Chin KCJ 

PROVIDER: S-EPMC5664820 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature