Assessment of the speed of flea kill of lotilaner (Credelio™) throughout the month following oral administration to dogs.

ABSTRACT: BACKGROUND:Lotilaner (Credelio™, Elanco), a novel isoxazoline, is a systemic insecticide and acaricide that is rapidly absorbed following oral administration to dogs and has a half-life of 30 days. As part of a development program, studies were undertaken to investigate lotilaner's initial and sustained efficacy and speed of kill against fleas. METHODS:Four studies were conducted to evaluate the onset of lotilaner's speed of flea knockdown at the time of treatment, and to determine the sustained speed of flea kill (SOK) up to 35 days post-treatment. Each study assessed one or two specific time points (4, 6, 8 and 12 h) post-treatment and following weekly re-infestations. In each study, dogs were randomised to a lotilaner or an untreated group based on pre-administration flea counts, and be

SUBMITTER: Cavalleri D 

PROVIDER: S-EPMC5664906 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature