Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice.

ABSTRACT:

Background

The aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on acetaminophen (APAP)-induced hepatotoxicity.

Methods

Seven-week-old male ddY mice were orally administered SE or saline (0.2 mL) once a day for a week. Twenty-four hours after the last pretreatment, the mice were intraperitoneally injected with 550 mg/kg APAP or saline under fasting conditions. The mice from each group were euthanized and bled for plasma analysis 2, 6, 24, and 72 h after the injection.

Results

We found that pretreatment with SE significantly decreased hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase), oxidative stress (malondialdehyde and glutathione level), inflammatory cytokines, histological damage

SUBMITTER: Yoshioka H 

PROVIDER: S-EPMC5664914 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature