Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [¹¹C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism.

ABSTRACT:

Introduction

Despite the decades long use of [¹¹C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published.

Methods

Dosimetry and biodistribution studies were performed in 2 pigs and 2 healthy volunteers by whole-body [¹¹C]palmitate PET scans. Metabolite studies were performed in 40 participants (healthy and with type 2 diabetes) under basal and hyperinsulinemic conditions. Metabolites were estimated using 2 approaches and subsequently compared: Indirect [¹¹C]CO₂ release and parent [¹¹C]palmitate measured by a solid-phase extraction (SPE) method. Finally, myocardial fatty acid uptake was calc

SUBMITTER: Christensen NL 

PROVIDER: S-EPMC5665104 | biostudies-literature | 2017 Jan-Dec

REPOSITORIES: biostudies-literature