O⁶-2'-Deoxyguanosine-butylene-O⁶-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

ABSTRACT: DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and for developing effective chemotherapies. Previous research has focused on ICLs cross-linked with the N7 and N2 atoms of guanine as well as those formed at the N6 atom of adenine; however, little is known about the mutagenicity of O⁶-dG-derived ICLs. Although less abundant, O⁶-alkylated guanine DNA lesions are chemically stable and highly mutagenic. Here, O⁶-2'-deoxyguanosine-butylene-O⁶-2'-deoxyguanosine (O⁶-dG-C4-O⁶-dG) is desig

SUBMITTER: Xu W 

PROVIDER: S-EPMC5665164 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature