Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden.

ABSTRACT: OBJECTIVE:Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs. Concerns have been raised about a potentially increased risk of gastric cancer following long-term use. Our aim is to assess the risk of gastric cancer associated with PPI use, taking into account underlying indications. DESIGN:This is a population-based cohort study. Standardised incidence ratios (SIRs) and 95% CIs were calculated to compare the risk of gastric cancer among long-term PPI users with the corresponding background population, while taking confounding by indication into account. SETTING:Population-based study in Sweden (2005-2012). PARTICIPANTS:This study included virtually all adults residing in Sweden exposed to maintenance therapy with PPIs. EXPOSURE/INTERVENTION:Maintenance use of PPIs, d

SUBMITTER: Brusselaers N 

PROVIDER: S-EPMC5665226 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature