Effectiveness of sitagliptin compared to sulfonylureas for type 2 diabetes mellitus inadequately controlled on metformin: a systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the effectiveness of sitagliptin compared to sulfonylureas as add-on to metformin in adults with type 2 diabetes mellitus from both randomised controlled trials (RCTs) and 'real-world' non-randomised studies.

Methods and analyses

We conducted a systematic review of EMBASE, MEDLINE, CENTRAL and grey literature for RCTs and non-randomised studies. We reported outcomes relating to change in HbA1c, fasting glucose, weight, blood pressure and lipids from baseline and need for treatment change. No study investigating macrovascular and microvascular diabetes complications was found. Meta-analysis was used where studies were sufficiently homogenous.

Results

Seven RCTs and five non-randomised studies were eligible for inclusion from 1335 articles retrieved.

SUBMITTER: Sharma M 

PROVIDER: S-EPMC5665259 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature