Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies.

ABSTRACT:

Background

There is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose-response relationship is still unclear.

Objective

To quantitatively investigate the relationship between dementia and PA.

Design

PubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose-response relationship using two stage generalised least squares regression.

Results

The primary analysis exhibited a dose-response trend for all-cause dementia (ACD), Alzheimer's disease (AD) but not for vascular dementia (VD). In the dose-response analysis, either ACD (p_trend</

SUBMITTER: Xu W 

PROVIDER: S-EPMC5665289 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature