Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice.

ABSTRACT: We examined the circulatory mechanisms underlying adaptive increases in thermogenic capacity in deer mice (Peromyscus maniculatus) native to the cold hypoxic environment at high altitudes. Deer mice from high- and low-altitude populations were born and raised in captivity to adulthood, and then acclimated to normoxia or hypobaric hypoxia (simulating hypoxia at ∼4300 m). Thermogenic capacity [maximal O₂ consumption (V̇_O2,max), during cold exposure] was measured in hypoxia, along with arterial O₂ saturation (Sa_O2 ) and heart rate (f_H). Hypoxia acclimation increased V̇_O2,max by a greater magnitude in highlanders than in lowlanders. Highlanders also had higher <

SUBMITTER: Tate KB 

PROVIDER: S-EPMC5665433 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature