The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes.

ABSTRACT: Because of their functional polarity and elongated morphologies, microtubule-based transport of proteins and organelles is critical for normal neuronal function. The proteasome is required throughout the neuron for the highly regulated degradation of a broad set of protein targets whose functions underlie key physiological responses, including synaptic plasticity and axonal degeneration. Molecularly, the relationship between proteasome transport and the transport of the targets of proteasomes is unclear. The dynein motor complex is required for the microtubule-based motility of numerous proteins and organelles in neurons. Here, we demonstrate that microtubule-based transport of proteasomes within the neuron in Drosophila utilizes a different dynein light chain to that used by synapt

SUBMITTER: Kreko-Pierce T 

PROVIDER: S-EPMC5665441 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature