Mosaic loss of non-muscle myosin IIA and IIB is sufficient to induce mammary epithelial proliferation.

ABSTRACT: The mammary epithelium elaborates through hormonally regulated changes in proliferation, migration and differentiation. Non-muscle myosin II (NMII) functions at the interface between contractility, adhesion and signal transduction. It is therefore a plausible regulator of mammary morphogenesis. We tested the genetic requirement for NMIIA and NMIIB in mammary morphogenesis through deletion of the three NMII heavy chain-encoding genes (NMHCIIA, NMHCIIB and NMHCIIC; also known as MYH9, MYH10 and MYH14, respectively) that confer specificity to the complex. Surprisingly, mosaic loss, but not ubiquitous loss, of NMHCIIA and NMHCIIB induced high levels of proliferation in 3D culture. This phenotype was observed even when cells were cultured

SUBMITTER: Nguyen-Ngoc KV 

PROVIDER: S-EPMC5665442 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature