Involvement of the enteroendocrine system in intestinal obstruction.

ABSTRACT:

Introduction

Intestinal atresia, a rare congenital condition, is often associated with intestinal motility disorders despite adequate neonatal surgery. Previous studies have focused on changes in the enteric nervous system (ENS). We hypothesized that other components of the digestive tract could be involved in this condition.

Material and methods

In a rat model of surgically-induced intestinal obstruction, a transcriptome analysis was performed to measure the global gene expression. Then, analyzes were focused on genes expressed in ENS and neuroendocrine cells. Rat fetus small intestines at different developmental stages (ED15, ED17, ED19 and ED21, (n = 22)) were studied as controls and compared to the upper and lower segments of small intestines from rat fetuses with surgic

SUBMITTER: Ballouhey Q 

PROVIDER: S-EPMC5665489 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature