Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study.

ABSTRACT:

Background

We previously reported gut dysbiosis in patients with Parkinson's disease (PD).

Objective

The aim of this study is to examine whether gut dysbiosis correlates with the progression of PD.

Methods

We examined changes in gut microbiota and demographic features in 2 years in 36 PD patients.

Results

A change of total UPDRS scores in 2 years was predicted by the counts of Bifidobacterium and Atopobium cluster at year 0 with a correlation coefficient of 0.52. Correlation analysis additionally revealed that low counts of Bifidobacterium and Bacteroides fragilis at year 0 were associated with worsening of UPDRS I scores in 2 years. In addition, low counts of Bifidobacterium at year 0 were associated with worsening of hallucinations/delusions in 2 years. Simil

SUBMITTER: Minato T 

PROVIDER: S-EPMC5665539 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature