Intramuscular Route of Administration Increases Potency in Eliciting Cocaine-Induced Behavioral Sensitization.

ABSTRACT:

Background

Cocaine is the number one abused psychostimulant drug that reaches addiction criterion in the US. In animals, repeated administration of cocaine results in behavioral sensitization which is thought to represent adaptations in the mesolimbic dopamine neural circuitry, the reward pathway. Cocaine-induced behavioral sensitization is evident in rodents and quail when cocaine is administered intraperitoneally (IP).

Objectives

The purpose of the current study was to investigate dose-dependent and temporal effects of acute and chronic intramuscular (IM) administration of cocaine in male quail.

Methods

After habituation to the test chambers, male quail received an IM injection of saline, 3 or 10 mg/kg cocaine and were immediately placed in the chambers. Distance tr

SUBMITTER: Rice BA 

PROVIDER: S-EPMC5665583 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature