The abundance of metabolites related to protein methylation correlates with the metastatic capacity of human melanoma xenografts.

ABSTRACT: Metabolic reprogramming is a major factor in transformation, and particular metabolic phenotypes correlate with oncogenotype, tumor progression, and metastasis. By profiling metabolites in 17 patient-derived xenograft melanoma models, we identified durable metabolomic signatures that correlate with biological features of the tumors. BRAF mutant tumors had metabolomic and metabolic flux features of enhanced glycolysis compared to BRAF wild-type tumors. Tumors that metastasized efficiently from their primary sites had elevated levels of metabolites related to protein methylation, including trimethyllysine (TML). TML levels correlated with histone H3 trimethylation at Lys⁹ and Lys²⁷, and methylation at these sites was also enhanced in efficiently metastasizing tumors. Er

SUBMITTER: Shi X 

PROVIDER: S-EPMC5665593 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature