Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal.

ABSTRACT: Hair follicle regeneration is dependent on reciprocal signaling between epithelial cells and underlying mesenchymal cells within the dermal papilla. Hair follicle dermal stem cells reside within the hair follicle mesenchyme, self-renew in vivo, and function to repopulate the dermal papilla and regenerate the connective tissue sheath with each hair cycle. The identity and temporal pattern of signals that regulate hair follicle dermal stem cell function are not known. Here, we show that platelet-derived growth factor signaling is crucial for hair follicle dermal stem cell function and platelet-derived growth factor deficiency results in a progressive depletion of the hair follicle dermal stem cell pool and their progeny. Using αSMACreER^T2:Rosa^YFP</

SUBMITTER: Gonzalez R 

PROVIDER: S-EPMC5665619 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature