¹⁸ F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study.

ABSTRACT:

Objective

¹⁸ F-flortaucipir (formerly ¹⁸ F-AV1451 or ¹⁸ F-T807) binds to neurofibrillary tangles in Alzheimer disease, but tissue studies assessing binding to tau aggregates in progressive supranuclear palsy (PSP) have yielded mixed results. We compared in vivo ¹⁸ F-flortaucipir uptake in patients meeting clinical research criteria for PSP (n = 33) to normal controls (n = 46) and patients meeting criteria for Parkinson disease (PD; n = 26).

Methods

Participants underwent magnetic resonance imaging and positron emission tomography for amyloid-β (¹¹ C-PiB or ¹⁸ F-florbetapir) and tau (¹⁸ F-flortaucipir). ¹⁸ F-flortaucipir standardized uptake value ratios were calculated (t = 80-100 minutes,

SUBMITTER: Schonhaut DR 

PROVIDER: S-EPMC5665658 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature