Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.

ABSTRACT:

Background

There is growing interest in white matter (WM) imaging with positron emission tomography (PET).

Objectives

We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding.

Methods

In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences.

Results

MS patients had lower memory ( p = 0.03) and language ( p = 0.02) performance; smaller thalamic volumes ( p = 0.003); and thinner temporal ( p = 0.001) and frontal ( p = 0.045) cortices on magnetic resona

SUBMITTER: Zeydan B 

PROVIDER: S-EPMC5665724 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature