Effects of dynamic matrix remodelling on en masse migration of fibroblasts on collagen matrices.

ABSTRACT: Fibroblast migration plays a key role during various physiological and pathological processes. Although migration of individual fibroblasts has been well studied, migration in vivo often involves simultaneous locomotion of fibroblasts sited in close proximity, so-called 'en masse migration', during which intensive cell-cell interactions occur. This study aims to understand the effects of matrix mechanical environments on the cell-matrix and cell-cell interactions during en masse migration of fibroblasts on collagen matrices. Specifically, we hypothesized that a group of migrating cells can significantly deform the matrix, whose mechanical microenvironment dramatically changes compared with the undeformed state, and the alteration of the matrix microenvironment reciprocally affects cell mig

SUBMITTER: Ozcelikkale A 

PROVIDER: S-EPMC5665820 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature