Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair.

ABSTRACT: Mechanical stress is one of the major aetiological factors underlying soft-tissue remodelling, especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress states lead to deviations from cellular homeostasis, resulting in subsequent cellular activation and extracellular matrix (ECM) remodelling. However, a quantitative link between alterations in the organ-level in vivo state and in vitro-based mechanobiology studies has yet to be made. We thus developed an integrated experimental-computational approach to elucidate MV tissue and interstitial cell responses to varying tissue strain levels. Comprehensive results at different length scales revealed that normal responses are observed only within a defined range of tissue deformations, whereas deformations outsi

SUBMITTER: Ayoub S 

PROVIDER: S-EPMC5665836 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature